Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox2  SRY (sex determining region Y)-box 2   (Synonyms: lcc, Sox-2, ysb)
Results	Reference
1	J:288334 Ando M, Goto M, Hojo M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S, The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development. J Mol Endocrinol. 2018 Oct 1;61(3):127-138
1	J:242500 Barford K, Yap CC, Dwyer ND, Winckler B, The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo. J Comp Neurol. 2017 Jun 01;525(8):1861-1878
1	J:305458 Bertacchi M, Romano AL, Loubat A, Tran Mau-Them F, Willems M, Faivre L, Khau van Kien P, Perrin L, Devillard F, Sorlin A, Kuentz P, Philippe C, Garde A, Neri F, Di Giaimo R, Oliviero S, Cappello S, D'Incerti L, Frassoni C, Studer M, NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients. EMBO J. 2020 Jul 1;39(13):e104163
1	J:196968 Campolo F, Gori M, Favaro R, Nicolis S, Pellegrini M, Botti F, Rossi P, Jannini EA, Dolci S, Essential role of Sox2 for the establishment and maintenance of the germ cell line. Stem Cells. 2013 Jul;31(7):1408-21
1	J:282102 Canizares MA, Albors AR, Singer G, Suttie N, Gorkic M, Felts P, Storey KG, Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal. J Anat. 2019 Oct 31;
1	J:202949 Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J, Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
1	J:163236 Cheng A, Scott AL, Ladenheim B, Chen K, Ouyang X, Lathia JD, Mughal M, Cadet JL, Mattson MP, Shih JC, Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. J Neurosci. 2010 Aug 11;30(32):10752-62
1	J:206806 Cheng CW, Niu B, Warren M, Pevny LH, Lovell-Badge R, Hwa T, Cheah KS, Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2596-601
1	J:262044 Chodelkova O, Masek J, Korinek V, Kozmik Z, Machon O, Tcf7L2 is essential for neurogenesis in the developing mouse neocortex. Neural Dev. 2018 May 11;13(1):8
1	J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
1	J:197151 Cloetta D, Thomanetz V, Baranek C, Lustenberger RM, Lin S, Oliveri F, Atanasoski S, Ruegg MA, Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013 May 1;33(18):7799-810
1	J:226819 Coate TM, Spita NA, Zhang KD, Isgrig KT, Kelley MW, Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons. Elife. 2015;4
1	J:264980 Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH 2nd, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec;22(23):4683-93
1	J:167041 Cook MS, Munger SC, Nadeau JH, Capel B, Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development. 2011 Jan;138(1):23-32
1	J:325442 Dai H, Zhu M, Li W, Si G, Xing Y, Activation of PI3K/p110alpha in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation. Front Cell Dev Biol. 2022;10:880206
1	J:171477 Davis SW, Mortensen AH, Camper SA, Birthdating studies reshape models for pituitary gland cell specification. Dev Biol. 2011 Apr 15;352(2):215-27
1	J:244825 Dennis DJ, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, Han S, Kovach C, Gruenig N, Kurrasch DM, Dyck RH, Schuurmans C, Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4934-E4943
1	J:236353 Dudok JJ, Murtaza M, Henrique Alves C, Rashbass P, Wijnholds J, Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res. 2016 Jul;108:12-23
1	J:226378 Falk S, Joosten E, Kaartinen V, Sommer L, Smad4 and Trim33/Tif1gamma redundantly regulate neural stem cells in the developing cortex. Cereb Cortex. 2014 Nov;24(11):2951-63
1	J:338186 Fang L, Kuniya T, Harada Y, Yasuda O, Maeda N, Suzuki Y, Kawaguchi D, Gotoh Y, TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone. Front Neurosci. 2023;17:1149603
1	J:220467 Galvis LA, Holik AZ, Short KM, Pasquet J, Lun AT, Blewitt ME, Smyth IM, Ritchie ME, Asselin-Labat ML, Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015 Apr 15;142(8):1458-69
1	J:334122 Glover JD, Sudderick ZR, Shih BB, Batho-Samblas C, Charlton L, Krause AL, Anderson C, Riddell J, Balic A, Li J, Klika V, Woolley TE, Gaffney EA, Corsinotti A, Anderson RA, Johnston LJ, Brown SJ, Wang S, Chen Y, Crichton ML, Headon DJ, The developmental basis of fingerprint pattern formation and variation. Cell. 2023 Mar 2;186(5):940-956.e20
1	J:227261 Gnedeva K, Hudspeth AJ, SoxC transcription factors are essential for the development of the inner ear. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14066-71
1	J:259888 Gnedeva K, Jacobo A, Salvi JD, Petelski AA, Hudspeth AJ, Elastic force restricts growth of the murine utricle. Elife. 2017 Jul 25;6:e25681
1	J:176045 Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL, Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct;138(19):4131-42
1	J:197815 Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR, beta-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci. 2012 Feb 15;125(Pt 4):932-42
1	J:253782 Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A, Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Sci Rep. 2016 Jun 1;6:26448
1	J:139866 Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH, Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007 Oct 11;1(4):443-57
1	J:203056 Hines EA, Jones MK, Verheyden JM, Harvey JF, Sun X, Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19444-9
1	J:253242 Hu XL, Chen G, Zhang S, Zheng J, Wu J, Bai QR, Wang Y, Li J, Wang H, Feng H, Li J, Sun X, Xia Q, Yang F, Hang J, Qi C, Phoenix TN, Temple S, Shen Q, Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells. Neuron. 2017 Jul 19;95(2):309-325.e6
1	J:193958 Huh SH, Narhi K, Lindfors PH, Haara O, Yang L, Ornitz DM, Mikkola ML, Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
1	J:306458 Jeong D, Lozano Casasbuenas D, Gengatharan A, Edwards K, Saghatelyan A, Kaplan DR, Miller FD, Yuzwa SA, LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex. Cell Rep. 2020 Oct 13;33(2):108257
1	J:252977 Jourdon A, Gresset A, Spassky N, Charnay P, Topilko P, Santos R, Prss56, a novel marker of adult neurogenesis in the mouse brain. Brain Struct Funct. 2016 Dec;221(9):4411-4427
1	J:196454 Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone G, Blais A, Slack RS, Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell Stem Cell. 2013 Apr 4;12(4):440-52
1*	J:194917 Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I, Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr;140(7):1424-32
1	J:219376 La Fata G, Gartner A, Dominguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C, FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci. 2014 Dec;17(12):1693-700
1	J:237343 Laresgoiti U, Nikolic MZ, Rao C, Brady JL, Richardson RV, Batchen EJ, Chapman KE, Rawlins EL, Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016 Oct 15;143(20):3686-3699
1	J:317151 Lavado A, Gangwar R, Pare J, Wan S, Fan Y, Cao X, YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development. Dev Biol. 2021 Dec;480:39-49
1	J:308018 Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV, Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Dev Dyn. 2021 Jul;250(7):1001-1020
1	J:242054 Lillien L, Rostral-caudal distribution of Emx1-lineage stem/transit amplifying cells and lineage progression in embryonic cortex depend on Hedgehog signaling. Dev Neurobiol. 2014 Nov;74(11):1096-109
1	J:146694 Lin YP, Ouchi Y, Satoh S, Watanabe S, Sox2 plays a role in the induction of amacrine and Muller glial cells in mouse retinal progenitor cells. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):68-74
1	J:307535 Liu X, Schneble-Lohnert N, Kristofova M, Qing X, Labisch J, Hofmann S, Ehrenberg S, Sannai M, Jorss T, Ori A, Godmann M, Wang ZQ, The N-terminal BRCT domain determines MCPH1 function in brain development and fertility. Cell Death Dis. 2021 Feb 1;12(2):143
1	J:160591 Liu Z, Owen T, Zhang L, Zuo J, Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neurons. Dev Dyn. 2010 Jun;239(6):1674-83
1	J:202909 Mansour SL, Li C, Urness LD, Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates. Genes Dev. 2013 Nov 1;27(21):2320-31
1	J:329932 Minati MA, Assi M, Libert M, Cordi S, Lemaigre F, Jacquemin P, KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood. Front Cell Dev Biol. 2022;10:995013
1	J:155518 Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF, Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21900-5
1	J:214809 Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B, Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
1	J:324129 Moreci RS, Lechler T, KIF18B is a cell type-specific regulator of spindle orientation in the epidermis. Mol Biol Cell. 2021 Nov 1;32(21):ar29
1*	J:151457 Nelson BR, Hartman BH, Ray CA, Hayashi T, Bermingham-McDonogh O, Reh TA, Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn. 2009 Feb 2;238(9):2163-2178
1	J:246292 Nishimura K, Noda T, Dabdoub A, Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea. PLoS One. 2017;12(1):e0170568
1	J:290493 Peng YR, James RE, Yan W, Kay JN, Kolodkin AL, Sanes JR, Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. Neuron. 2020 Feb 5;105(3):464-474.e6
1	J:331420 Pijuan I, Balducci E, Soto-Sanchez C, Fernandez E, Barallobre MJ, Arbones ML, Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome. Sci Rep. 2022 Nov 19;12(1):19912
1	J:266669 Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P, Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10142-10147
1	J:215784 Sennett R, Rezza A, Dauber KL, Clavel C, Rendl M, Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation. Exp Dermatol. 2014 Oct;23(10):748-50
1	J:308820 Shohayeb B, Ho UY, Hassan H, Piper M, Ng DCH, The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus. Front Cell Dev Biol. 2020;8:549353
1	J:325182 Smith RJ, Zhang H, Hu SS, Yung T, Francis R, Lee L, Onaitis MW, Dirks PB, Zang C, Kim TH, Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions. Nat Commun. 2022 May 26;13(1):2965
1	J:217677 Snitow ME, Li S, Morley MP, Rathi K, Lu MM, Kadzik RS, Stewart KM, Morrisey EE, Ezh2 represses the basal cell lineage during lung endoderm development. Development. 2015 Jan 1;142(1):108-17
1	J:316648 Suflita MT, Pfaltzgraff ER, Mundell NA, Pevny LH, Labosky PA, Ground-state transcriptional requirements for skin-derived precursors. Stem Cells Dev. 2013 Jun 15;22(12):1779-88
1	J:286609 Tait CM, Chinnaiya K, Manning E, Murtaza M, Ashton JP, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS, Furley A, Rashbass P, Das RM, Storey KG, Placzek M, Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal. PLoS Biol. 2020 Mar;18(3):e3000470
1*	J:297267 Tang Q, Xu M, Xu J, Xie X, Yang H, Gan L, Gfi1-GCE inducible Cre line for hair cell-specific gene manipulation in mouse inner ear. Genesis. 2019 Sep;57(9):e23304
1	J:227032 Tateya T, Sakamoto S, Imayoshi I, Kageyama R, In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium. Hear Res. 2015 Sep;327:209-17
1	J:293532 Vaid S, Camp JG, Hersemann L, Eugster Oegema C, Heninger AK, Winkler S, Brandl H, Sarov M, Treutlein B, Huttner WB, Namba T, A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex. Development. 2018 Oct 18;145(20):dev169276
1	J:290308 van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV, Yap and its subcellular localization have distinct compartment-specific roles in the developing lung. Development. 2019 May 1;146(9):dev175810
1	J:256150 Voronova A, Yuzwa SA, Wang BS, Zahr S, Syal C, Wang J, Kaplan DR, Miller FD, Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017 May 3;94(3):500-516.e9
1	J:147427 Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y, Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci. 2009 Apr 8;29(14):4484-97
1	J:217501 Vue TY, Kim EJ, Parras CM, Guillemot F, Johnson JE, Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord. Development. 2014 Oct;141(19):3721-31
1	J:302429 Wang Z, Jung JS, Inbar TC, Rangoussis KM, Faaborg-Andersen C, Coate TM, The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development. eNeuro. 2020 Jul/Aug;7(4):ENEURO.0179-20.2020
1	J:206319 Welcker JE, Hernandez-Miranda LR, Paul FE, Jia S, Ivanov A, Selbach M, Birchmeier C, Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
1	J:293436 Wilson SL, Kalinovsky A, Orvis GD, Joyner AL, Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types. Cerebellum. 2011 Sep;10(3):356-72
1	J:173796 Yamamoto N, Chang W, Kelley MW, Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol. 2011 May 15;353(2):367-79
1	J:272387 Yang LM, Huh SH, Ornitz DM, FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Dev Cell. 2018 Sep 10;46(5):564-580.e5
1*	J:203658 Yariz KO, Duman D, Seco CZ, Dallman J, Huang M, Peters TA, Sirmaci A, Lu N, Schraders M, Skromne I, Oostrik J, Diaz-Horta O, Young JI, Tokgoz-Yilmaz S, Konukseven O, Shahin H, Hetterschijt L, Kanaan M, Oonk AM, Edwards YJ, Li H, Atalay S, Blanton S, Desmidt AA, Liu XZ, Pennings RJ, Lu Z, Chen ZY, Kremer H, Tekin M, Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet. 2012 Nov 2;91(5):872-82
1	J:341147 Young RE, Jones MK, Hines EA, Li R, Luo Y, Shi W, Verheyden JM, Sun X, Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell. 2020 Apr 6;53(1):73-85.e5
1	J:315083 Yu X, Cates JM, Morrissey C, You C, Grabowska MM, Zhang J, DeGraff DJ, Strand DW, Franco OE, Lin-Tsai O, Hayward SW, Matusik RJ, SOX2 expression in the developing, adult, as well as, diseased prostate. Prostate Cancer Prostatic Dis. 2014 Dec;17(4):301-9
1	J:332095 Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Chuang PT, mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. Nat Commun. 2022 Nov 25;13(1):7252
1	J:266585 Zheng J, Nie X, He L, Yoon AJ, Wu L, Zhang X, Vats M, Schiff MD, Xiang L, Tian Z, Ling J, Mao JJ, Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis. J Dent Res. 2018 Nov;97(12):1346-1354
1	J:287133 Zhu X, Tollkuhn J, Taylor H, Rosenfeld MG, Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland. Stem Cell Reports. 2015 Dec 8;5(6):1196-1209
1	J:347415 Zocher S, McCloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer MW, Toda T, Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024 Apr 5;384(6691):53-59
1*	J:140027 Zou D, Erickson C, Kim EH, Jin D, Fritzsch B, Xu PX, Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56